Molecular portraits of human breast tumours. Screening for breast cancer with mammography. Some triple-negative breast cancers are thought to have a degree of BRCA-ness resulting in faulty DNA repair pathways, conferring similar increased sensitivity to regimens containing platinum salts, which cause DNA damage via the production of interstrand DNA cross-links. Drug development has focused on targeting several of these mechanisms of resistance. Bioinformatics, Big Data, and Cancer. It is not possible to make definitive conclusions about the benefits of breast surgery associated with medical treatment for women with metastatic breast cancer. Sign in to customize your interests Sign in to your personal account. Peer Review and Funding Outcomes. Combination chemotherapy is uncommonly used in the treatment of mBC, but select combinations have been shown to be effective in producing swifter and more significant responses compared with single-agent chemotherapy.
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EMA to Decide if Lynparza Can Treat BRCA-mutated Metastatic Breast Cancer Patients
Converting cancer therapies into cures: Study characteristics The evidence is current to February These studies demonstrate how translational science can inform clinical trial design and how biologic activity can translate into clinical efficacy; however, pharmacological specificity is crucial because off-target toxic effects hinder clinical applicability. Research Tools, Specimens, and Data. First-line gemcitabine versus epirubicin in postmenopausal women aged 60 or older with metastatic breast cancer: Integration of clinical trial participation in oncologic care is a critical element in the development of new treatment options for patients with advanced disease. N Engl J Med. Tips and Tools for Health Care Professionals Epigenetic signatures differentiate triple negative breast cancers. Anti-tumour activity of phosphoinositidekinase antagonist AEZS in models of triple-negative breast cancer.
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Multicenter phase II study of apatinib in non-triple-negative metastatic breast cancer. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Preoperative chemotherapy for women with operable breast cancer. Although response evaluation criteria in solid tumors RECIST is required by most clinical trials to assess for disease progression, clinicians could reasonably use similar thresholds before abandoning a given line of treatment. The primary outcomes were overall survival and quality of life. Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. Breast surgery was believed to be palliative and performed only to relieve symptoms such as local bleeding, infection, or pain. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer. Phase II trial of bicalutamide in patients with androgen receptor-positive, estrogen receptor-negative metastatic Breast Cancer.
Description:We also searched ClinicalTrials. When a new primary cancer occurs in a person with a history of cancer, it is known as a second primary cancer. Daily oral etoposide in patients with heavily pretreated metastatic breast cancer. Resources for News Media. Radiotherapy 6 Early breast cancer 6 Hypofractionated radiation therapy for early breast cancer. Post-operative radiotherapy 2 Intensity-modulated versus conventional radiotherapy for breast cancer protocol stage. Metastatic breast cancer is considered an incurable disease with poor prognosis , although some women can live for many years. Patients in the eribulin treatment arm had an OS that approached clinical significance when compared to those receiving capecitabine New Directions in Targeting Angiogenesis.